Interleukin-31 and interleukin-31 receptor: New therapeutic targets for atopic dermatitis

Mechanisims of asthma and allergic disease – 1064. Interleukin 31 (IL 31) serum levels in atopic dermatitis patients

Background Atopic dermatitis is a common chronic skin disorder which is a subset of atopy. Atopy refers to a genetic predisposition to respond immunonologically to allergens which are generally harmless, causingover production of immunoglobulin E (IgE) antibodies. IgE synthesis is dependent on the activation of CD4+ Th2 subset and their secretion of cytokines including IL 4 and IL 13. This stud...

Correlation between serum interleukin-31 level and the severity of disease in children with atopic dermatitis

INTRODUCTION Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD. ...

Functional regulation of interleukin-31 production by its genetic polymorphism in patients with extrinsic atopic dermatitis.

Association of LL-37 and IL-31 serum levels with SCORing Atopic Dermatitis (SCORAD) score in atopic dermatitis patients

Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31)in atopic dermatitis. The studies on atopic dermatitis are still limited i...

Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children

PURPOSE Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. METHODS We enrolled 91 children with AD and 32 contro...